Spen Gene Summary [Mouse]
Enables DNA-binding transcription factor activity; single-stranded DNA binding activity; and transcription corepressor activity. Involved in random inactivation of X chromosome. Acts upstream of or within negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in central nervous system; genitourinary system; hemolymphoid system; sensory organ; and tooth. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human SPEN (spen family transcriptional repressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spen |
| Official Name | spen family transcription repressor [Source:MGI Symbol;Acc:MGI:1891706] |
| Ensembl ID | ENSMUSG00000040761 |
| Bio databases IDs | |
| Aliases | spen family transcription repressor |
| Synonyms | HIAA0929, LOC100365546, MINT, mKIAA0929, RATARS, RBM15C, RGD1564662, SHARP, spen family transcriptional repressor, spen family transcription repressor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spen often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Msx2 binding domain
- RNA recognition motif (RRM) superfamily
- Family of unknown function (DUF5585)
- transcription regulator
- RAM domain
- Spen paralog and ortholog C-terminal domain
- SPOC domain
- RNA recognition motif
- transcription co-repressor
- transcription factor binding
- protein binding
- U2 snRNP auxilliary factor, large subunit, splicing factor
- SPOC (Spen paralog and ortholog C-terminal) domain superfamily
- RecF/RecN/SMC N terminal domain
- receptor binding domain
- transcription repression domain
- single-stranded DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- adenoid cystic carcinoma of salivary gland
- salivary gland cancer
- epithelial cancer
- Radio-Tartaglia syndrome
- hereditary disorder
- neoplasia
- prostatic carcinoma
- prostate cancer
- metastasis
role in cell
- expression in
- activation in
- proliferation
- reverse transcription
- differentiation
- morphology
- cell viability
- fusion
- reverse transcription in
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spen gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- Notch signaling pathway
- negative regulation of transcription, DNA-dependent
- positive regulation of neurogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- transcriptional repressor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- transcription corepressor activity
- mRNA binding