Ralgds Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in brush border; cytosol; and nucleus. Predicted to be active in plasma membrane. Is expressed in several structures, including blastocyst; early embryo; nervous system; ovary; and retina. Orthologous to human RALGDS (ral guanine nucleotide dissociation stimulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ralgds |
| Official Name | ral guanine nucleotide dissociation stimulator [Source:MGI Symbol;Acc:MGI:107485] |
| Ensembl ID | ENSMUSG00000026821 |
| Bio databases IDs | |
| Aliases | ral guanine nucleotide dissociation stimulator |
| Synonyms | Gnds, Hs.560937, LOC102554500, mKIAA1308, RalGDSB, RalGEF, ral guanine nucleotide dissociation stimulator, RGDS, RGF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ralgds often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase regulator
- Ras-binding domain
- PDK-1 binding domain
- Ral binding domain
- guanyl-nucleotide exchange factor
- Ubl1_cv_Nsp3_N-like
- Ras/Rap binding domain
- protein binding
- RasGEF
- Rap1 binding domain
- REM
- active-Ras binding domain
Pathways
Biological processes and signaling networks where the Ralgds gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
role in cell
- growth
- activation in
- proliferation
- differentiation
- migration
- adhesion
- anoikis
- colony formation
- outgrowth
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ralgds gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Ras protein signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- brush border
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- GTPase regulator activity