Rap1b Gene Summary [Mouse]
Enables G protein activity. Involved in modification of postsynaptic structure. Acts upstream of or within several processes, including negative regulation of regulated secretory pathway; positive regulation of ERK1 and ERK2 cascade; and small GTPase-mediated signal transduction. Is active in glutamatergic synapse. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including RAP1B (RAP1B, member of RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rap1b |
| Official Name | RAS related protein 1b [Source:MGI Symbol;Acc:MGI:894315] |
| Ensembl ID | ENSMUSG00000052681 |
| Bio databases IDs | |
| Aliases | RAS related protein 1b |
| Synonyms | 2810443E11Rik, K-REV, RAL1B, RAP1B, member of RAS oncogene family, RAS related protein 1b, THC11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rap1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- binding protein
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rap1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Bladder Cancer Signaling
- Chemokine Signaling
- CNTF Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- ErbB Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- PPAR Signaling
- Prolactin Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- sickle cell anemia
- essential thrombocythemia
- thrombocytopenia type 11 with multiple congenital anomalies and dysmorphic facies
- breast cancer
- vascular leak syndrome
- glomerulosclerosis
- oral cancer
- endometriosis
- bleeding
role in cell
- phosphorylation in
- proliferation
- quantity
- accumulation in
- growth
- migration
- activation in
- generation in
- production in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- intercellular junctions
- secretory granule membrane
- lipid droplets
- cytosol
- cytoplasmic face of plasma membrane
- Golgi membrane
- lysosome membrane
- growth cone
- nerve ending
- membrane rafts
- perikaryon
- axons
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rap1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- negative regulation of calcium ion-dependent exocytosis
- establishment of endothelial barrier
- cellular response to cAMP
- positive regulation of ERK1 and ERK2 cascade
- microvillus assembly
- calcium ion-dependent exocytosis
- Rap protein signal transduction
- establishment of localization in cell
- positive regulation of integrin activation
- negative regulation of synaptic vesicle exocytosis
- regulation of establishment of cell polarity
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cell-cell junction
- extracellular vesicular exosome
- membrane raft
- membrane
- cytosol
- azurophil granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- GDP binding