Crat Gene Summary [Mouse]

Predicted to enable acyl-CoA oxidase activity and carnitine O-acetyltransferase activity. Predicted to be involved in carnitine metabolic process, CoA-linked and fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Crat
Official Name
carnitine acetyltransferase [Source:MGI Symbol;Acc:MGI:109501]
Ensembl ID
ENSMUSG00000026853
Bio databases IDs NCBI: 12908 Ensembl: ENSMUSG00000026853
Aliases carnitine acetyltransferase
Synonyms Acetyl Carnitine Transferase, Act, CARAT, CARNITINE ACETYLTRANSFERASE, carnitine O-acetyltransferase, CAT, CAT1, NBIA8
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • acyl-CoA oxidase
  • carnitine O-acetyltransferase
  • Choline/Carnitine o-acyltransferase
  • enzyme

Pathways

Biological processes and signaling networks where the Crat gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • weight gain
  • myelodysplastic syndrome
  • androgenic alopecia
  • psoriasis
  • carnitine acetyltransferase deficiency
  • neurodegeneration with brain iron accumulation 8
  • neurodegeneration with brain iron accumulation
regulated by
regulates
  • D-glucose
  • carbon
  • acetyl-coenzyme A
  • corticosterone
  • 4,8-dimethylnonanoyl-CoA
  • acetyl-L-carnitine
  • fatty acid
  • oleic acid
  • non-esterified fatty acid
  • short chain fatty acid
role in cell
  • oxidation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • peroxisomal matrix
  • Endoplasmic Reticulum
  • Mitochondria
  • cytosol
  • endoplasmic reticulum membrane
  • mitochondrial membrane
  • mitochondrial inner membrane
  • peroxisomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Crat gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • fatty acid beta-oxidation using acyl-CoA oxidase
  • carnitine metabolic process, CoA-linked
  • medium-chain fatty acid metabolic process
  • short-chain fatty acid metabolic process

Cellular Component

Where in the cell the gene product is active
  • peroxisome
  • mitochondrion
  • cytosol
  • endoplasmic reticulum
  • peroxisomal matrix
  • mitochondrial inner membrane

Molecular Function

What the gene product does at the molecular level
  • carnitine O-acetyltransferase activity
  • acyl-CoA oxidase activity
  • carnitine O-octanoyltransferase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.