Crat Gene Summary [Rat]
Enables carnitine O-acetyltransferase activity. Involved in fatty acid metabolic process. Predicted to be located in mitochondrion. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crat |
| Official Name | carnitine O-acetyltransferase [Source:RGD Symbol;Acc:1303031] |
| Ensembl ID | ENSRNOG00000018145 |
| Bio databases IDs | |
| Aliases | carnitine O-acetyltransferase |
| Synonyms | Acetyl Carnitine Transferase, Act, CARAT, CARNITINE ACETYLTRANSFERASE, carnitine O-acetyltransferase, CAT, CAT1, NBIA8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acyl-CoA oxidase
- carnitine O-acetyltransferase
- Choline/Carnitine o-acyltransferase
- enzyme
Pathways
Biological processes and signaling networks where the Crat gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- myelodysplastic syndrome
- androgenic alopecia
- psoriasis
- carnitine acetyltransferase deficiency
- neurodegeneration with brain iron accumulation 8
- neurodegeneration with brain iron accumulation
regulates
- D-glucose
- carbon
- acetyl-coenzyme A
- corticosterone
- 4,8-dimethylnonanoyl-CoA
- acetyl-L-carnitine
- fatty acid
- oleic acid
- non-esterified fatty acid
- short chain fatty acid
role in cell
- oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrial inner membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation using acyl-CoA oxidase
- carnitine metabolic process, CoA-linked
- medium-chain fatty acid metabolic process
- short-chain fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- mitochondrion
- cytosol
- endoplasmic reticulum
- peroxisomal matrix
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- carnitine O-acetyltransferase activity
- acyl-CoA oxidase activity
- carnitine O-octanoyltransferase activity