Traf1 Gene Summary [Mouse]
Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and tumor necrosis factor receptor binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity; regulation of signal transduction; and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Is expressed in jaw and urinary system. Orthologous to human TRAF1 (TNF receptor associated factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Traf1 |
| Official Name | TNF receptor-associated factor 1 [Source:MGI Symbol;Acc:MGI:101836] |
| Ensembl ID | ENSMUSG00000026875 |
| Bio databases IDs | |
| Aliases | TNF receptor-associated factor 1 |
| Synonyms | 4732496E14Rik, EBI6, ineligibletraf1, MGC:10353, TNF receptor-associated factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Traf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TNF receptor-associated factor BIRC3 binding domain
- ubiquitin protein ligase binding
- MATH
- tumor necrosis factor receptor binding
- enzyme binding
- TRAF domain
- protein binding
- identical protein binding
- TRAF-C subdomain
Pathways
Biological processes and signaling networks where the Traf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD40 Signaling
- Induction of Apoptosis by HIV1
- Lymphotoxin β Receptor Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Small Cell Lung Cancer Signaling
- TNFR2 Signaling
- Toll-like Receptor Signaling
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- rheumatoid arthritis
- asthma
- systemic juvenile idiopathic arthritis
- systemic lupus erythematosus
- experimental intestinal endometriosis
- allergic asthma
- respiratory disorder
role in cell
- proliferation
- expression in
- production in
- activation in
- signaling in
- apoptosis
- number
- differentiation
- cellular infiltration by
- oligomerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- insoluble fractions
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Traf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- macromolecular complex assembly
- apoptotic process
- regulation of extrinsic apoptotic signaling pathway
- regulation of I-kappaB kinase/NF-kappaB cascade
- protein K63-linked ubiquitination
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- tumor necrosis factor receptor binding
- thioesterase binding