Exoc5 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Involved in protein localization to plasma membrane. Acts upstream of or within with a positive effect on establishment of planar polarity. Acts upstream of or within with a negative effect on epithelial cell apoptotic process. Acts upstream of or within homeostasis of number of cells within a tissue; morphogenesis of a polarized epithelium; and non-motile cilium assembly. Predicted to be located in cytosol. Predicted to be part of exocyst. Is expressed in 1-cell stage embryo; cerebral cortex ventricular layer; cortical plate; primary oocyte; and secondary oocyte. Used to study obstructive nephropathy. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Exoc5 |
| Official Name | exocyst complex component 5 [Source:MGI Symbol;Acc:MGI:2145645] |
| Ensembl ID | ENSMUSG00000061244 |
| Bio databases IDs | |
| Aliases | exocyst complex component 5 |
| Synonyms | AI447711, exocyst complex component 5, Gm76, HSEC10, PRO1912, SEC10, SEC10L1, SEC10P |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Exoc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- Exocyst complex component Sec10
- protein binding
Pathways
Biological processes and signaling networks where the Exoc5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- renal fibrosis
- Hutchinson-Gilford progeria syndrome
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
role in cell
- expression in
- phosphorylation in
- number
- loss
- formation
- formation in
- apoptosis
- morphology
- assembly
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomal bud
- perinuclear region
- vesicles
- cytosol
- trans Golgi network
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Exoc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- cytokinesis after mitosis
- establishment of planar polarity
- vesicle docking involved in exocytosis
- protein transport
- Golgi to plasma membrane transport
- post-Golgi vesicle-mediated transport
- exocytosis
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- midbody
- exocyst
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding