P2rx3 Gene Summary [Mouse]
Enables extracellularly ATP-gated monoatomic cation channel activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within several processes, including neuromuscular synaptic transmission; response to ATP; and smooth muscle contraction. Located in axon. Is active in Schaffer collateral - CA1 synapse and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including branchial arch; embryo ectoderm; gut; nervous system; and retina. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | P2rx3 |
| Official Name | purinergic receptor P2X, ligand-gated ion channel, 3 [Source:MGI Symbol;Acc:MGI:1097160] |
| Ensembl ID | ENSMUSG00000027071 |
| Bio databases IDs | |
| Aliases | purinergic receptor P2X, ligand-gated ion channel, 3 |
| Synonyms | 4930513E20RIK, LOC100862344, P2X3, P2X3 receptor, purinergic receptor P2X 3, purinergic receptor P2X, ligand-gated ion channel, 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse P2rx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP P2X receptor
- purinergic nucleotide receptor
- ATP binding
- ATP-gated cation channel
- protein binding
- identical protein binding
- ion channel
Pathways
Biological processes and signaling networks where the P2rx3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- metabolic syndrome X
- chronic cough
- inflammatory hyperalgesia
- pain
- hyperalgesia
- insomnia
- valvulopathy
- coronary artery disease
- allodynia
regulates
- Ca2+
- adenosine triphosphate
- cation
- NFkB (complex)
- ion
- INS
- inorganic cation
- P2RX3
role in cell
- activation in
- depolarization
- action potential
- response by
- synaptic transmission
- electrical capacitance
- plasticity
- sensitization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- presynaptic membrane
- dendritic spines
- neurites
- nerve ending
- synapse
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse P2rx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- sensory perception of taste
- purinergic nucleotide receptor signaling pathway
- neuromuscular synaptic transmission
- signal transduction
- response to carbohydrate stimulus
- response to mechanical stimulus
- positive regulation of calcium-mediated signaling
- response to cold
- response to heat
- response to hypoxia
- behavioral response to pain
- regulation of synaptic plasticity
- calcium ion transmembrane transport
- positive regulation of calcium ion transport into cytosol
- establishment of localization in cell
- protein homotrimerization
- cellular response to ATP
- peristalsis
- urinary bladder smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- receptor complex
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular ATP-gated cation channel activity
- ATP binding
- purinergic nucleotide receptor activity