Meis1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of myeloid cell differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and lens morphogenesis in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study restless legs syndrome. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Meis1 |
| Official Name | Meis homeobox 1 [Source:MGI Symbol;Acc:MGI:104717] |
| Ensembl ID | ENSMUSG00000020160 |
| Bio databases IDs | |
| Aliases | Meis homeobox 1 |
| Synonyms | C530044H18Rik, Evi8, LOC108352805, LOC679409, Meis1a, Meis1b, Meis homeobox 1, Myeloid ecotropic viral integration site-related gene 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Meis1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- N-terminal of Homeobox Meis and PKNOX1
- homeodomain
- DNA binding
Pathways
Biological processes and signaling networks where the Meis1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- movement disorder
- restless legs syndrome
- left ventricular systolic dysfunction
- insomnia
- endometriosis
- colorectal cancer
- non-insulin-dependent diabetes mellitus
- neoplastic cell transformation
- periodic limb movement disorder
role in cell
- differentiation
- expression in
- quantity
- proliferation
- cell death
- accumulation in
- colony formation
- number
- cell cycle progression
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Meis1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of myeloid cell differentiation
- hemopoiesis
- embryonic pattern specification
- positive regulation of cell proliferation
- negative regulation of neuron differentiation
- brain development
- cell growth involved in cardiac muscle cell development
- positive regulation of transcription from RNA polymerase II promoter
- lens morphogenesis in camera-type eye
- definitive hemopoiesis
- organ morphogenesis
- eye development
- locomotory behavior
- angiogenesis
- megakaryocyte development
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity