Nop10 Gene Summary [Mouse]
Predicted to enable box H/ACA snoRNA binding activity and telomerase RNA binding activity. Predicted to be involved in snRNA pseudouridine synthesis; snoRNA guided rRNA pseudouridine synthesis; and telomere maintenance via telomerase. Predicted to be located in nuclear body. Predicted to be part of box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 1. Orthologous to human NOP10 (NOP10 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nop10 |
| Official Name | NOP10 ribonucleoprotein [Source:MGI Symbol;Acc:MGI:1913431] |
| Ensembl ID | ENSMUSG00000027133 |
| Bio databases IDs | |
| Aliases | NOP10 ribonucleoprotein |
| Synonyms | 1110036B12Rik, CHINE2, DKCB1, LOC687899, NOLA3, NOP10P, NOP10 ribonucleoprotein, PFBMFT9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nop10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- snoRNA binding
- protein binding
- Nucleolar RNA-binding protein, Nop10p family
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- telomere-related pulmonary fibrosis and/or bone marrow failure syndrome type 9
- autosomal recessive dyskeratosis congenita type 1
- cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 2
role in cell
- telomere-length maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- dense fibrillar component
- nucleoplasm
- nucleoli
- nuclear bodies
- Cajal bodies
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nop10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pseudouridine synthesis
- rRNA pseudouridine synthesis
- snRNA pseudouridine synthesis
- telomere maintenance via telomerase
Cellular Component
Where in the cell the gene product is active
- box H/ACA snoRNP complex
- nuclear body
- box H/ACA scaRNP complex
- telomerase holoenzyme complex
- small nucleolar ribonucleoprotein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- telomeric RNA binding
- box H/ACA snoRNA binding