Lin7c Gene Summary [Mouse]
Predicted to enable cytoskeletal protein binding activity; protein domain specific binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within neurotransmitter secretion. Is active in glutamatergic synapse. Is expressed in brain; brainstem nucleus; and midbrain ventricular layer. Orthologous to human LIN7C (lin-7 homolog C, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lin7c |
| Official Name | lin-7 homolog C (C. elegans) [Source:MGI Symbol;Acc:MGI:1330839] |
| Ensembl ID | ENSMUSG00000027162 |
| Bio databases IDs | |
| Aliases | lin-7 homolog C (C. elegans) |
| Synonyms | 9130007B12Rik, D2Ertd520e, lin-7 homolog C, crumbs cell polarity complex component, MALS-3, VELI3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lin7c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- cytoskeletal protein binding
- canonical PDZ domain
- protein domain specific binding
- protein binding
- PDZ domain
- PDZ-domain binding
- L27 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- tubulo-interstitial fibrosis
- polyuria
- infection by HIV-1
role in cell
- activity
- polarity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoplasmic vesicle membrane
- presynaptic regions
- perinuclear membrane
- postsynaptic region
- cellular membrane
- Plasma Membrane
- intercellular junctions
- cytosol
- synapse
- axodendritic synapses
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lin7c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maintenance of epithelial cell apical/basal polarity
- protein transport
- morphogenesis of an epithelial sheet
- exocytosis
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- tight junction
- MPP7-DLG1-LIN7 complex
- cell-cell junction
- cytoplasm
- synapse
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- L27 domain binding
- cytoskeletal protein binding