Crb3 Gene Summary [Mouse]
Predicted to enable SH3 domain binding activity. Involved in positive regulation of cell junction assembly. Located in apical part of cell. Part of subapical complex. Is expressed in several structures, including central nervous system; early conceptus; and retina. Orthologous to human CRB3 (crumbs cell polarity complex component 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crb3 |
| Official Name | crumbs family member 3 [Source:MGI Symbol;Acc:MGI:2670904] |
| Ensembl ID | ENSMUSG00000044279 |
| Bio databases IDs | |
| Aliases | crumbs family member 3 |
| Synonyms | 5730439B18, AU015179, AU041752, crumbs cell polarity complex component 3, crumbs family member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- FERM domain binding motif
- transmembrane domain
- protein domain specific binding
- protein binding
- PDZ binding motif
- SH3-domain binding
- Sh3 domain binding motif
Pathways
Biological processes and signaling networks where the Crb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cyanosis
- tubulo-interstitial fibrosis
- dyspnea
role in cell
- phosphorylation in
- invasion by
- proliferation
- migration
- formation
- organization
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- cilia
- apical compartment
- cellular membrane
- Plasma Membrane
- centrosome
- primary cilia
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment or maintenance of epithelial cell apical/basal polarity
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- tight junction
- subapical complex
- extracellular vesicular exosome
- apical junction complex
- cell junction
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- SH3 domain binding