Hdc Gene Summary [Mouse]
Enables histidine decarboxylase activity. Acts upstream of or within L-histidine catabolic process and histamine biosynthetic process. Predicted to be located in dendrite and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study Gilles de la Tourette syndrome. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdc |
| Official Name | histidine decarboxylase [Source:MGI Symbol;Acc:MGI:96062] |
| Ensembl ID | ENSMUSG00000027360 |
| Bio databases IDs | |
| Aliases | histidine decarboxylase |
| Synonyms | Hdc-a, Hdc-c, Hdc-e, Hdc-s, histidine decarboxylase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hdc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- pyridoxal phosphate binding
- ER targeting sequence
- AAT_I
- enzyme
- protein binding
- identical protein binding
- histidine decarboxylase
- amino acid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- experimental autoimmune encephalomyelitis
- allergy
- psoriasis
- anorexia
- malaria
- cardiac hypertrophy
- indolent systemic mastocytosis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- obesity
role in cell
- expression in
- quantity
- accumulation
- aggregation
- abnormal morphology
- number
- resorption by
- sequestration
- size
- clearance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hdc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- histidine metabolic process
- histidine catabolic process
- cellular amino acid metabolic process
- catecholamine biosynthetic process
- histamine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein binding
- histidine decarboxylase activity