Ndufaf5 Gene Summary [Mouse]
Predicted to enable monooxygenase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly and peptidyl-arginine hydroxylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 16. Orthologous to human NDUFAF5 (NADH:ubiquinone oxidoreductase complex assembly factor 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufaf5 |
| Official Name | NADH:ubiquinone oxidoreductase complex assembly factor 5 [Source:MGI Symbol;Acc:MGI:1916737] |
| Ensembl ID | ENSMUSG00000027384 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase complex assembly factor 5 |
| Synonyms | 2310003L22Rik, bA526K24.2, C20orf7, dJ842G6.1, MC1DN16, NADH:ubiquinone oxidoreductase complex assembly factor 5, RGD1309829 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndufaf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- monooxygenase
- AdoMet_MTases
- protein binding
- ubiE/COQ5 methyltransferase family
- malonyl-acyl carrier protein O-methyltransferase BioC
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- mitochondrial disorder
- nuclear type 16 mitochondrial complex I deficiency
- Lebers optic atrophy plus syndrome
- Mitochondrial complex I deficiency
- hereditary disorder
- Leigh syndrome
- Huntington disease
- endometriosis
- insulin resistance
regulates
- Mitochondrial ETC 1
- NDUFS7
role in cell
- hydroxylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndufaf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex I assembly
- peptidyl-arginine hydroxylation
- methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity
- S-adenosylmethionine-dependent methyltransferase activity