Zhx2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Involved in retinal bipolar neuron differentiation. Acts upstream of or within negative regulation of macromolecule biosynthetic process; negative regulation of neuron differentiation; and somatic stem cell population maintenance. Is active in nucleus. Is expressed in brain; liver; and renal vasculature. Orthologous to human ZHX2 (zinc fingers and homeoboxes 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zhx2 |
| Official Name | zinc fingers and homeoboxes 2 [Source:MGI Symbol;Acc:MGI:2683087] |
| Ensembl ID | ENSMUSG00000071757 |
| Bio databases IDs | |
| Aliases | zinc fingers and homeoboxes 2 |
| Synonyms | AFR1, KIAA0854, mKIAA0854, RAF, THC2378933, zinc fingers and homeoboxes 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zhx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc-fingers and homeoboxes C2H2 finger domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Ras-binding domain
- protein homodimerization
- protein binding
- homeodomain
- identical protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cancer
- neoplasia
- breast cancer
- ovarian cancer
- liver damage
- tumorigenesis
- metastasis
- major depression
- lung injury
role in cell
- production in
- phosphorylation in
- apoptosis
- expression in
- proliferation
- invasion by
- morphology
- differentiation
- growth
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zhx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- retinal bipolar neuron differentiation
- negative regulation of transcription, DNA-dependent
- negative regulation of neuron differentiation
- somatic stem cell maintenance
- mRNA catabolic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- metal ion binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity