Mrgbp Gene Summary [Mouse]
Predicted to be involved in positive regulation of double-strand break repair via homologous recombination; regulation of cell cycle; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of NuA4 histone acetyltransferase complex and nucleosome. Orthologous to human MRGBP (MRG domain binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrgbp |
| Official Name | MRG/MORF4L binding protein [Source:MGI Symbol;Acc:MGI:1920497] |
| Ensembl ID | ENSMUSG00000027569 |
| Bio databases IDs | |
| Aliases | MRG/MORF4L binding protein |
| Synonyms | 1600027N09Rik, C20orf20, Eaf7, MRG15BP, MRG domain binding protein, MRG/MORF4L binding protein, NEWGENE 1308612, RGD1308612, URCC4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mrgbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin modification-related protein EAF7
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mrgbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of cell cycle
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- NuA4 histone acetyltransferase complex
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding