Epc2 Gene Summary [Mouse]

Predicted to be involved in positive regulation of double-strand break repair via homologous recombination; regulation of cell cycle; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex; nucleosome; and piccolo histone acetyltransferase complex. Orthologous to human EPC2 (enhancer of polycomb homolog 2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Epc2
Official Name
enhancer of polycomb homolog 2 [Source:MGI Symbol;Acc:MGI:1278321]
Ensembl ID
ENSMUSG00000069495
Bio databases IDs NCBI: 227867 Ensembl: ENSMUSG00000069495
Aliases enhancer of polycomb homolog 2
Synonyms 5830499L14, D2Ertd694e, DKFZP566F2124, enhancer of polycomb homolog 2, EPC-LIKE
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Enhancer of polycomb-like
  • Enhancer of Polycomb C-terminus

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-insulin-dependent diabetes mellitus
  • schizophrenia
  • tumorigenesis
regulated by
role in cell
  • cell cycle progression

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleosomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Epc2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • DNA repair
  • positive regulation of transcription, DNA-dependent
  • regulation of double-strand break repair
  • regulation of apoptotic process
  • regulation of cell cycle
  • chromatin organization
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • NuA4 histone acetyltransferase complex
  • Piccolo NuA4 histone acetyltransferase complex
  • nucleosome