Ralgapb Gene Summary [Mouse]
Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol. Is expressed in central nervous system and retina. Orthologous to human RALGAPB (Ral GTPase activating protein non-catalytic subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ralgapb |
| Official Name | Ral GTPase activating protein, beta subunit (non-catalytic) [Source:MGI Symbol;Acc:MGI:2444531] |
| Ensembl ID | ENSMUSG00000027652 |
| Bio databases IDs | |
| Aliases | Ral GTPase activating protein, beta subunit (non-catalytic) |
| Synonyms | B230339M05Rik, KIAA1219, LOC100364646, LOC103691958, p170, RalGAPbeta, Ral GTPase activating protein, beta subunit (non-catalytic), Ral GTPase activating protein non-catalytic subunit beta, Ral GTPase activating protein non-catalytic subunit β, Ral GTPase activating protein, β subunit (non-catalytic), RGD1306861 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ralgapb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase activator
- protein binding
- protein heterodimerization
- RALGAPB N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- mental retardation
- metabolic disorder
- septo-optic dysplasia
role in cell
- migration
- phosphorylation in
- expression in
- invasion by
- production in
- capivasertib resistance
- autophagy by
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ralgapb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- GTPase activator activity