RALGAPB Gene Summary [Human]
Enables protein heterodimerization activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within Ral protein signal transduction; regulation of exocyst localization; and regulation of protein localization. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RALGAPB |
| Official Name | Ral GTPase activating protein non-catalytic subunit beta [Source:HGNC Symbol;Acc:HGNC:29221] |
| Ensembl ID | ENSG00000170471 |
| Bio databases IDs | |
| Aliases | Ral GTPase activating protein non-catalytic subunit beta |
| Synonyms | B230339M05Rik, KIAA1219, LOC100364646, LOC103691958, p170, RalGAPbeta, Ral GTPase activating protein, beta subunit (non-catalytic), Ral GTPase activating protein non-catalytic subunit beta, Ral GTPase activating protein non-catalytic subunit β, Ral GTPase activating protein, β subunit (non-catalytic), RGD1306861 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RALGAPB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase activator
- protein binding
- protein heterodimerization
- RALGAPB N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- mental retardation
- metabolic disorder
- septo-optic dysplasia
role in cell
- migration
- phosphorylation in
- expression in
- invasion by
- production in
- capivasertib resistance
- autophagy by
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RALGAPB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- GTPase activator activity