Fam83d Gene Summary [Mouse]
Predicted to enable kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Predicted to be located in cytoplasm; intercellular bridge; and mitotic spindle. Predicted to be active in cytosol and mitotic spindle pole. Is expressed in cerebral cortex ventricular layer; diencephalon lateral wall ventricular layer; midbrain ventricular layer; olfactory epithelium; and telencephalon ventricular layer. Orthologous to human FAM83D (family with sequence similarity 83 member D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam83d |
| Official Name | family with sequence similarity 83, member D [Source:MGI Symbol;Acc:MGI:1919128] |
| Ensembl ID | ENSMUSG00000027654 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 83, member D |
| Synonyms | 2310007D09Rik, C20orf129, CHICA, dJ616B8.3, family with sequence similarity 83 member D, family with sequence similarity 83, member D, RGD1565583 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fam83d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IxI/V motif
- microtubule binding
- protein kinase binding
- FAM83 A-H
- PLD-like domain
- protein binding
- Catalytic domain of phospholipase D superfamily proteins
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- glioblastoma
- glioblastoma cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- breast cancer
- survival
- renal clear cell adenocarcinoma
regulates
role in cell
- proliferation
- G1 phase
- misorientation
- misorientation in
- chromosomal congression
- misalignment in
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- spindle apparatus
- cytoplasmic bridges
- cytosol
- spindle pole
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fam83d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cell proliferation
- regulation of ERK1 and ERK2 cascade
- metaphase plate congression
- signal transduction
- regulation of protein catabolic process
- epithelial to mesenchymal transition
- cell migration
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- microtubule cytoskeleton
- mitotic spindle
- cytoplasm
- spindle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- kinesin binding
- microtubule binding