FAM83D Gene Summary [Human]
Enables kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Located in cytosol; intercellular bridge; and mitotic spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FAM83D |
| Official Name | family with sequence similarity 83 member D [Source:HGNC Symbol;Acc:HGNC:16122] |
| Ensembl ID | ENSG00000101447 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 83 member D |
| Synonyms | 2310007D09Rik, C20orf129, CHICA, dJ616B8.3, family with sequence similarity 83 member D, family with sequence similarity 83, member D, RGD1565583 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FAM83D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IxI/V motif
- microtubule binding
- protein kinase binding
- FAM83 A-H
- PLD-like domain
- protein binding
- Catalytic domain of phospholipase D superfamily proteins
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- neoplasia
- glioblastoma
- glioblastoma cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- breast cancer
- survival
- renal clear cell adenocarcinoma
regulates
role in cell
- proliferation
- G1 phase
- misorientation
- misorientation in
- chromosomal congression
- misalignment in
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- spindle apparatus
- cytoplasmic bridges
- cytosol
- spindle pole
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FAM83D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cell proliferation
- regulation of ERK1 and ERK2 cascade
- metaphase plate congression
- signal transduction
- regulation of protein catabolic process
- epithelial to mesenchymal transition
- cell migration
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- microtubule cytoskeleton
- mitotic spindle
- cytoplasm
- spindle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- kinesin binding
- microtubule binding