Dhx35 Gene Summary [Mouse]
Predicted to enable RNA binding activity and helicase activity. Acts upstream of or within in utero embryonic development. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human DHX35 (DEAH-box helicase 35). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhx35 |
| Official Name | DEAH (Asp-Glu-Ala-His) box polypeptide 35 [Source:MGI Symbol;Acc:MGI:1918965] |
| Ensembl ID | ENSMUSG00000027655 |
| Bio databases IDs | |
| Aliases | DEAH (Asp-Glu-Ala-His) box polypeptide 35 |
| Synonyms | 1200009D07Rik, C20orf15, DDX35, DEAH-box helicase 35, KAIA0875 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dhx35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Helicase associated domain (HA2) Add an annotation
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dhx35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- catalytic step 2 spliceosome
- intracellular
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- RNA helicase activity
- helicase activity