Etfdh Gene Summary [Mouse]
Predicted to enable 4 iron, 4 sulfur cluster binding activity; electron-transferring-flavoprotein dehydrogenase activity; and ubiquinone binding activity. Involved in response to oxidative stress. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Etfdh |
| Official Name | electron transferring flavoprotein, dehydrogenase [Source:MGI Symbol;Acc:MGI:106100] |
| Ensembl ID | ENSMUSG00000027809 |
| Bio databases IDs | |
| Aliases | electron transferring flavoprotein, dehydrogenase |
| Synonyms | 0610010I20Rik, electron transfer flavoprotein dehydrogenase, Electron-Transfer Flavoprotein-Ubiquinone Oxidoreductase, electron transferring flavoprotein, dehydrogenase, ETFQO, MADD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Etfdh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 4Fe-4S dicluster domain
- electron carrier
- flavin adenine dinucleotide binding
- quinone binding
- binding protein
- oxidoreductase
- ubiquinone binding
- electron-transferring-flavoprotein dehydrogenase
- enzyme
- protein binding
- Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
- geranylgeranyl reductase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- glutaric aciduria type 2
- glutaric acidemia type 2C
- hereditary disorder
- hypertrophic cardiomyopathy
- late-onset glutaric acidemia type 2C
- non-insulin-dependent diabetes mellitus
- hepatitis B virus-related hepatocellular carcinoma
- bipolar disorder
role in cell
- growth
- tubulation
- tubulation in
- fragmentation in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Etfdh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- fatty acid beta-oxidation using acyl-CoA dehydrogenase
- respiratory electron transport chain
- electron transport chain
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrial matrix
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- quinone binding
- oxidoreductase activity
- flavin adenine dinucleotide binding
- metal ion binding
- electron carrier activity
- electron-transferring-flavoprotein dehydrogenase activity
- 4 iron, 4 sulfur cluster binding
- ubiquinone binding