Klf6 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of connective tissue replacement. Acts upstream of or within cytokine-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and peripheral nervous system. Human ortholog(s) of this gene implicated in prostate cancer and stomach cancer. Orthologous to human KLF6 (KLF transcription factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klf6 |
| Official Name | Kruppel-like factor 6 [Source:MGI Symbol;Acc:MGI:1346318] |
| Ensembl ID | ENSMUSG00000000078 |
| Bio databases IDs | |
| Aliases | Kruppel-like factor 6 |
| Synonyms | Aa1017, BCD1, C86813, CBA1, COPEB, CPBP, Erythropoietin 1, FM2, FM6, GBF, Ierepo1, IEREPO3, KLF transcription factor 6, Kruppel-like transcription factor 6, KRUPPEL LIKE ZINC FINGER protein ZF9, PAC1, PROTO-ONCOGENE BCD, Proto-oncogene BCD1, R75280, ST12, ZF9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- transcription activation domain
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins
- zinc finger domain
- p53-binding domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Klf6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- metastasis
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- neoplasia
- tumorigenesis
- fibrosis
- COVID-19
role in cell
- expression in
- transactivation in
- production in
- cell viability
- activation in
- binding in
- degradation in
- proliferation
- transcription in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- positive regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleolus
- chromatin
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity