Ptpn22 Gene Summary [Mouse]
Enables SH3 domain binding activity; kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including dephosphorylation; regulation of cytokine production; and regulation of intracellular signal transduction. Acts upstream of or within T cell differentiation and T cell receptor signaling pathway. Located in cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); graft-versus-host disease; and pulmonary tuberculosis. Orthologous to human PTPN22 (protein tyrosine phosphatase non-receptor type 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ptpn22 |
| Official Name | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) [Source:MGI Symbol;Acc:MGI:107170] |
| Ensembl ID | ENSMUSG00000027843 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) |
| Synonyms | 70zpep, LYP, LYP1, PEP, protein tyrosine phosphatase non-receptor type 22, protein tyrosine phosphatase, non-receptor type 22, protein tyrosine phosphatase, non-receptor type 22 (lymphoid), Protein tyrosine phosphatase non-receptor type 8, PTPN8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein kinase binding
- protein-tyrosine-phoshatase
- catalytic domain
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- protein binding
- proline rich domain
- Protein tyrosine phosphatase, catalytic domain motif
- SH3-domain binding
- Sh3 domain binding motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- kinase binding
- phosphatase
Pathways
Biological processes and signaling networks where the Ptpn22 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- endometriosis
- chronic lymphocytic leukemia
- neoplasia
- epithelial cancer
- Crohn disease
- susceptibility to rheumatoid arthritis
- rheumatoid arthritis
- vitiligo
- late-onset myasthenia gravis
role in cell
- phosphorylation in
- expression in
- apoptosis
- transcription in
- proliferation
- production in
- differentiation
- signaling in
- growth
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- cytoplasmic face of plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of JUN kinase activity
- autophagy
- positive regulation of interferon-gamma production
- regulation of B cell receptor signaling pathway
- T cell receptor signaling pathway
- negative regulation of tumor necrosis factor production
- positive regulation of toll-like receptor 3 signaling pathway
- positive regulation of toll-like receptor 4 signaling pathway
- positive regulation of type I interferon production
- protein dephosphorylation
- positive regulation of NLRP3 inflammasome complex assembly
- negative regulation of interleukin-6 production
- T cell differentiation
- negative regulation of gene expression
- negative regulation of T cell receptor signaling pathway
- negative regulation of interleukin-8 production
- positive regulation of gene expression
- negative regulation of autophagy
- lipid metabolic process
- regulation of innate immune response
- positive regulation of ERK1 and ERK2 cascade
- regulation of natural killer cell proliferation
- lipopolysaccharide-mediated signaling pathway
- response to lipopolysaccharide
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- cellular response to muramyl dipeptide
- negative regulation of T cell activation
- phosphoanandamide dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- phosphatase activity
- SH3 domain binding
- kinase binding