Cd247 Gene Summary [Mouse]
Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein tyrosine kinase binding activity. Acts upstream of or within T cell receptor signaling pathway and positive regulation of protein localization to cell surface. Located in Golgi apparatus and plasma membrane. Part of alpha-beta T cell receptor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in immunodeficiency 25. Orthologous to human CD247 (CD247 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd247 |
| Official Name | CD247 antigen [Source:MGI Symbol;Acc:MGI:88334] |
| Ensembl ID | ENSMUSG00000005763 |
| Bio databases IDs | |
| Aliases | CD247 antigen |
| Synonyms | 4930549J05RIK, A430104F18RIK, CD16Z, CD247 antigen, CD247 molecule, Cd3, CD3H, CD3 NU, CD3Q, CD3Z, CD3-ZETA, CD3-ζ, IMD25, T3Z, Tcrk, TCRZ, TCRzeta, Tcr ζ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd247 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein kinase binding
- T-cell activation motif
- Antigen receptor homology 1 domain
- tyrosine activation motif
- T-cell surface glycoprotein CD3 zeta chain
- protein binding
- identical protein binding
- itam like domain
- cytoplasmic domain
- basic amino acid motif
- transmembrane domain
- Immunoreceptor tyrosine-based activation motif
- intracellular domain
- protein homodimerization
- tail domain
- signaling domain
- membrane-proximal domain
- transmembrane receptor
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Cd247 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Antiproliferative Role of TOB in T Cell Signaling
- Autoimmune Thyroid Disease Signaling
- Calcium-induced T Lymphocyte Apoptosis
- CCR5 Signaling in Macrophages
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Dendritic Cell Maturation
- G Protein Signaling Mediated by Tubby
- Glucocorticoid Receptor Signaling
- Graft-versus-Host Disease Signaling
- Lipid Antigen Presentation by CD1
- Natural Killer Cell Signaling
- NF-κB Signaling
- Nur77 Signaling in T Lymphocytes
- OX40 Signaling Pathway
- PKCθ Signaling in T Lymphocytes
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- SAPK/JNK Signaling
- Systemic Lupus Erythematosus Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- relapsed acute lymphocytic leukemia
- acute lymphoblastic lymphoma
- rheumatoid arthritis
- systemic lupus erythematosus
- asthma
- Waldenström macroglobulinemia
- precursor B-cell acute lymphoblastic leukemia
- immunodeficiency due to defect in CD3-zeta
- undifferentiated acute leukemia
- relapsed B cell acute lymphoblastic leukemia
role in cell
- proliferation
- cell death
- signaling in
- apoptosis
- quantity
- formation
- cytotoxicity
- production in
- expression in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- raft fractions
- soluble fraction
- membrane fraction
- Cytoplasm
- cell surface
- pericentrosomal region
- intracellular space
- cellular membrane
- vesicles
- lysosome
- Golgi Apparatus
- microsome
- membrane rafts
- detergent-soluble fraction
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd247 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gamma-delta T cell activation
- macromolecular complex assembly
- positive regulation of protein localization at cell surface
- Fc-gamma receptor signaling pathway
- adaptive immune response
- cell surface receptor signaling pathway
- alpha-beta T cell activation
- protein oligomerization
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- Fc-gamma receptor III complex
- cytoplasm
- Golgi apparatus
- T cell receptor complex
- alpha-beta T cell receptor complex
- plasma membrane
- gamma-delta T cell receptor complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transmembrane signaling receptor activity
- protein homodimerization activity
- protein binding
- protein heterodimerization activity