Ptgfrn Gene Summary [Mouse]
Involved in myoblast fusion involved in skeletal muscle regeneration. Acts upstream of or within lipid droplet organization. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in several structures, including central nervous system; glans of male genital tubercle; palatal shelf; skeleton; and submandibular gland primordium. Orthologous to human PTGFRN (prostaglandin F2 receptor inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptgfrn |
| Official Name | prostaglandin F2 receptor negative regulator [Source:MGI Symbol;Acc:MGI:1277114] |
| Ensembl ID | ENSMUSG00000027864 |
| Bio databases IDs | |
| Aliases | prostaglandin F2 receptor negative regulator |
| Synonyms | 4833445A08RIK, CD315, CD9P-1, CD9 partner 1, EWI-F, FPRP, prostaglandin F2 receptor inhibitor, prostaglandin F2 receptor negative regulator, SMAP-6, Trim45 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptgfrn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- CD19_double_Ig
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- epithelial cancer
- liver cancer
- prostate cancer
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- essential tremor
- idiopathic pulmonary fibrosis
- prostatic carcinoma
- impotence
role in cell
- accumulation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- extracellular vesicles
- cell surface
- cell-cell contacts
- apical cell surfaces
- endoplasmic reticulum membrane
- uropod
- Golgi membrane
- trans Golgi network
- microsomal membrane
- microvilli
- microspikes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptgfrn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myoblast fusion involved in skeletal muscle regeneration
- lipid particle organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- Golgi apparatus
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding