Cd151 Gene Summary [Mouse]
Predicted to enable integrin binding activity. Acts upstream of or within T cell proliferation and cell migration. Predicted to be located in basement membrane and cell surface. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex. Orthologous to human CD151 (CD151 molecule (Raph blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Cd151 |
| Official Name | CD151 antigen [Source:MGI Symbol;Acc:MGI:1096360] |
| Ensembl ID | ENSMUSG00000025510 |
| Bio databases IDs | |
| Aliases | CD151 antigen |
| Synonyms | CD151 antigen, CD151 molecule (Raph blood group), EBS7, GP27, LOC100911730, MER2, p27, PETA-3, Platelet endothelial tetraspan antigen-3, RAPH, SFA-1, TSPAN24 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd151 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoylation site
- tetraspanin_LEL
- cytoplasmic domain
- integrin binding
- protein binding
- Tetraspanin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- tubulo-interstitial fibrosis
- hyperplasia
- edema
- aortic valve calcification
- angioimmunoblastic T-cell lymphoma
- lung metastasis
role in cell
- migration
- expression in
- phosphorylation in
- growth
- activation in
- proliferation
- apoptosis
- cell viability
- function
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum fraction
- Golgi-enriched fraction
- membrane fraction
- actin-rich protrusion
- Cytoplasm
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- intercellular junctions
- hemidesmosomes
- cell-cell contacts
- granules
- ER-to-Golgi intermediate compartment
- cytosol
- cell membrane-lagging edges
- lateral plasma membrane
- cis face of the Golgi apparatus
- cis Golgi networks
- neurites
- early endosomes
- late endosomes
- cytoplasmic vesicles
- anchoring junction
- lateral cell-cell contacts
- membrane rafts
- cellular protrusions
- filopodia
- cell-cell adherens junctions
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd151 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing, spreading of cells
- positive regulation of endocytosis
- T cell proliferation
- cell adhesion
- cell migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- basement membrane
- focal adhesion
- membrane
- cytosol
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding