Cd81 Gene Summary [Mouse]
Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of receptor clustering; and syncytium formation by plasma membrane fusion. Acts upstream of or within regulation of cell motility. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd81 |
| Official Name | CD81 antigen [Source:MGI Symbol;Acc:MGI:1096398] |
| Ensembl ID | ENSMUSG00000037706 |
| Bio databases IDs | |
| Aliases | CD81 antigen |
| Synonyms | CD81 antigen, CD81 molecule, CVID6, S5.7, TAPA1, TSPAN28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd81 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC class II protein binding
- tetraspanin_LEL
- cholesterol binding
- viral receptor
- cytoplasmic domain
- integrin binding
- transmembrane domain
- extracellular loop
- protein binding
- receptor binding
- Tetraspanin family
Pathways
Biological processes and signaling networks where the Cd81 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- proteinuria
- non-insulin-dependent diabetes mellitus
- early-onset preeclampsia
- psoriatic arthritis
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- peritoneal endometriosis
- cutaneous melanoma
role in cell
- activation in
- phosphorylation in
- binding in
- expression in
- proliferation
- migration
- formation in
- quantity
- transcription in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- tetraspanin-enriched microdomain
- intracellular structures
- Cytoplasm
- cell surface
- cell periphery
- microvesicles
- membrane surface
- cellular membrane
- focal adhesions
- vesicles
- intercellular junctions
- immunological synapses
- cytosol
- apical membrane
- uropod
- basolateral membrane
- basal membrane
- neurites
- multivesicular bodies
- microsomal membrane
- membrane rafts
- exosomes
- podocyte slit diaphragm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd81 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- CD4-positive, alpha beta T cell costimulation
- positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- positive regulation of MAPK cascade
- positive regulation of transcription from RNA polymerase II promoter
- immunological synapse formation
- positive regulation of B cell receptor signaling pathway
- humoral immune response mediated by circulating immunoglobulin
- positive regulation of inflammatory response to antigenic stimulus
- positive regulation of T cell receptor signaling pathway
- regulation of protein stability
- osteoclast fusion
- myoblast fusion involved in skeletal muscle regeneration
- positive regulation of protein exit from endoplasmic reticulum
- positive regulation of B cell proliferation
- receptor internalization
- cellular response to low-density lipoprotein particle stimulus
- positive regulation of CD4-positive, alpha-beta T cell proliferation
- protein localization in plasma membrane
- macrophage fusion
- positive regulation of T-helper 2 cell cytokine production
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- extracellular vesicular exosome
- focal adhesion
- membrane
- vesicle
- basolateral plasma membrane
- tetraspanin-enriched microdomain
- plasma membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding
- viral receptor activity
- integrin binding
- MHC class II protein binding
- MHC class II protein complex binding