Pnn Gene Summary [Mouse]
Predicted to enable DNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to act upstream of or within cell-cell adhesion. Located in cytoplasm and nuclear speck. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human PNN (pinin, desmosome associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pnn |
| Official Name | pinin [Source:MGI Symbol;Acc:MGI:1100514] |
| Ensembl ID | ENSMUSG00000020994 |
| Bio databases IDs | |
| Aliases | pinin |
| Synonyms | D12Ertd512e, DRS, DRSP, memA, PIN-1, pinin, pinin, desmosome associated protein, SDK3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pnn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- serine-rich region
- pinin/SDK/memA/ protein conserved region
- coiled-coil domain
- pinin/SDK conserved region
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- severe acute respiratory syndrome
role in cell
- expression in
- growth
- adhesion
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- catalytic step 2 spliceosome
- Cytoplasm
- intranuclear region
- perinuclear region
- Nucleus
- intermediate filaments
- intercellular junctions
- desmosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pnn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- exon-exon junction complex
- cell-cell junction
- catalytic step 2 spliceosome
- nuclear speck
- membrane
- intermediate filament
- desmosome
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- structural molecule activity