Rpl15 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in cerebellum external granule cell layer; liver; neural retina; olfactory epithelium; and pancreas. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 12. Orthologous to human RPL15 (ribosomal protein L15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl15 |
| Official Name | ribosomal protein L15 [Source:MGI Symbol;Acc:MGI:1913730] |
| Ensembl ID | ENSMUSG00000012405 |
| Bio databases IDs | |
| Aliases | ribosomal protein L15 |
| Synonyms | 2510008H07Rik, DBA12, EC45, eL15, EST814117, L15, ribosomal protein L15, RPL10, RPLY10, RPYL10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- protein binding
- Ribosomal L15
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Diamond-Blackfan anemia type 12
- primary open-angle glaucoma
- rheumatoid arthritis
- Parkinson disease
- myelodysplastic syndrome
role in cell
- proliferation
- number
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- cellular membrane
- ribosome
- Nucleus
- sarcomere
- cytosol
- nucleoli
- nuclear envelope
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to ethanol
- cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytoplasm
- cytosol
- cytosolic large ribosomal subunit
- synapse
- A band
- ribosome
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- structural constituent of ribosome
- cadherin binding