Mcub Gene Summary [Mouse]
Enables calcium channel inhibitor activity. Involved in several processes, including mitochondrial calcium ion transmembrane transport; negative regulation of calcium import into the mitochondrion; and positive regulation of skeletal muscle satellite cell differentiation. Located in membrane and mitochondrion. Part of calcium channel complex. Orthologous to human MCUB (mitochondrial calcium uniporter dominant negative subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcub |
| Official Name | mitochondrial calcium uniporter dominant negative beta subunit [Source:MGI Symbol;Acc:MGI:1914065] |
| Ensembl ID | ENSMUSG00000027994 |
| Bio databases IDs | |
| Aliases | mitochondrial calcium uniporter dominant negative beta subunit |
| Synonyms | 9030408N13Rik, CCDC109B, mitochondrial calcium uniporter dominant negative beta subunit, mitochondrial calcium uniporter dominant negative subunit beta, mitochondrial calcium uniporter dominant negative subunit β, mitochondrial calcium uniporter dominant negative β subunit, RGD1305326 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcub often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium channel inhibitor
- protein binding
- Mitochondrial calcium uniporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- peripheral arterial disease
- COVID-19
- coronary artery disease
- streptozotocin-induced diabetes
- uterine leiomyoma
- leiomyomatosis
- age-related macular degeneration
- cardiovascular disorder
regulated by
- mir-223
- epigallocatechin-gallate
- MI-2-2
- PKD1
regulates
- Ca2+
- D-glucose
- PLN
role in cell
- phosphorylation in
- differentiation
- activation
- oxidation in
- metabolism in
- transport in
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Mitochondria
- cytosol
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcub gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macrophage activation
- mitochondrial calcium ion homeostasis
- mitochondrial calcium ion transport
- skeletal muscle tissue regeneration
Cellular Component
Where in the cell the gene product is active
- calcium channel complex
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ion channel activity
- calcium channel inhibitor activity