Pear1 Gene Summary [Mouse]
Enables signaling receptor activity. Involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction; platelet aggregation; and positive regulation of platelet activation. Acts upstream of or within recognition of apoptotic cell. Located in phagocytic cup. Is active in plasma membrane. Is expressed in brain; dorsal root ganglion; embryo; heart; and spinal cord. Orthologous to human PEAR1 (platelet endothelial aggregation receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Pear1 |
| Official Name | platelet endothelial aggregation receptor 1 [Source:MGI Symbol;Acc:MGI:1920432] |
| Ensembl ID | ENSMUSG00000028073 |
| Bio databases IDs | |
| Aliases | platelet endothelial aggregation receptor 1 |
| Synonyms | 3110045G13Rik, JEDI, Jedi-1, MEGF12, platelet endothelial aggregation receptor 1, RGD1305653 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pear1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- EMI domain
- protein binding
- Serine Proline motif
- EGF_CA
- Laminin EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast carcinoma
- invasive breast carcinoma
- invasive breast cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- papillary renal cell carcinoma
role in cell
- expression in
- phosphorylation in
- phagocytosis
- aggregation
- expansion
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- lamellipodia
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pear1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of platelet activation
- protein kinase B signaling cascade
- recognition of apoptotic cell
- platelet aggregation
Cellular Component
Where in the cell the gene product is active
- membrane
- phagocytic cup
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity