Rab25 Gene Summary [Mouse]
Predicted to enable GTP binding activity; GTPase activity; and myosin V binding activity. Involved in epithelial cell morphogenesis. Predicted to be located in cytoplasmic vesicle; plasma membrane; and pseudopodium. Predicted to be active in Golgi apparatus and recycling endosome. Is expressed in gut; nasal cavity epithelium; skin; submandibular gland primordium; and urinary system. Orthologous to human RAB25 (RAB25, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab25 |
| Official Name | RAB25, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1858203] |
| Ensembl ID | ENSMUSG00000008601 |
| Bio databases IDs | |
| Aliases | RAB25, member RAS oncogene family |
| Synonyms | AV012978, CATX-8, RAB11C, RAB25, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- small monomeric GTPase
- 50S ribosome-binding GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- AAA domain
- myosin binding
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- endometriosis
- esophageal atresia
- hyperplasia
role in cell
- proliferation
- expression in
- migration
- formation
- activation in
- reorganization in
- invasion
- morphogenesis
- invasion by
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- Plasma Membrane
- recycling endosomes
- cytoplasmic vesicles
- pseudopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- protein transport
- epithelial cell morphogenesis
- positive regulation of epithelial cell migration
- regulation of vesicle-mediated transport
- exocytosis
- pseudopodium organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- pseudopodium membrane
- cytoplasmic vesicle
- Golgi apparatus
- recycling endosome
- pseudopodium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- myosin V binding