Runx3 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of epithelial cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of alpha-beta T cell differentiation. Acts upstream of or within several processes, including chondrocyte differentiation; hair follicle morphogenesis; and positive regulation of extrinsic apoptotic signaling pathway. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study asthma; idiopathic scoliosis; and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Runx3 |
| Official Name | runt related transcription factor 3 [Source:MGI Symbol;Acc:MGI:102672] |
| Ensembl ID | ENSMUSG00000070691 |
| Bio databases IDs | |
| Aliases | runt related transcription factor 3 |
| Synonyms | AML2, CBFA3, CBF-alpha 3, CBF-α 3, PEA2-alpha C, PEA2-α C, Pebp2a3, PEBP2aC, Pebp2 α C, runt related transcription factor 3, RUNX family transcription factor 3, Rx3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Runx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- transcription factor binding
- histone deacetylase binding
- runt domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Runx inhibition domain
- double-stranded DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Runx3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- adenoma formation
- benign neoplasia
- alopecia
- ulcerative colitis
- inflammatory bowel disease
role in cell
- expression in
- transactivation in
- differentiation
- activation in
- phosphorylation in
- migration
- inhibition
- quantity
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Runx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- hemopoiesis
- chondrocyte differentiation
- negative regulation of cell cycle
- regulation of transcription, DNA-dependent
- positive regulation of CD8-positive, alpha-beta T cell differentiation
- protein phosphorylation
- peripheral nervous system neuron development
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell differentiation
- negative regulation of CD4-positive, alpha-beta T cell differentiation
- ossification
- positive regulation of transcription, DNA-dependent
- negative regulation of epithelial cell proliferation
- response to transforming growth factor beta stimulus
Cellular Component
Where in the cell the gene product is active
- core-binding factor complex
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- ATP binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity