Hoxc9 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification and embryonic skeletal system morphogenesis. Predicted to be located in aggresome and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; extraembryonic component; genitourinary system; limb; and nervous system. Orthologous to human HOXC9 (homeobox C9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxc9 |
| Official Name | homeobox C9 [Source:MGI Symbol;Acc:MGI:96199] |
| Ensembl ID | ENSMUSG00000036139 |
| Bio databases IDs | |
| Aliases | homeobox C9 |
| Synonyms | homeobox C9, HOX3, Hox-3.2, HOX3B, HOXC8, LOC100912116 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hoxc9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- Hox9 activation region
- protein binding
- Hox hexapeptide motif
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Hoxc9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- soft tissue sarcoma cancer
- clear cell sarcoma of the kidney
- renal cancer
- kyphosis
- growth failure
- Cornelia de Lange syndrome
role in cell
- proliferation
- expression in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- aggresome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hoxc9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- anterior/posterior pattern specification
- negative regulation of cell cycle
- embryonic skeletal system morphogenesis
- proximal/distal pattern formation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- chromatin
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity