Ercc5 Gene Summary [Mouse]
Predicted to enable several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Acts upstream of or within UV protection; determination of adult lifespan; and nucleotide-excision repair. Predicted to be located in chromosome. Predicted to be part of DNA replication factor A complex and nucleotide-excision repair complex. Predicted to be active in nucleus. Is expressed in central nervous system; genitourinary system; and retina. Used to study xeroderma pigmentosum group G. Human ortholog(s) of this gene implicated in several diseases, including cerebrooculofacioskeletal syndrome 3; melanoma; respiratory system cancer (multiple); stomach cancer; and xeroderma pigmentosum group G. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ercc5 |
| Official Name | excision repair cross-complementing rodent repair deficiency, complementation group 5 [Source:MGI Symbol;Acc:MGI:103582] |
| Ensembl ID | ENSMUSG00000026048 |
| Bio databases IDs | |
| Aliases | excision repair cross-complementing rodent repair deficiency, complementation group 5 |
| Synonyms | COFS3, ERCC excision repair 5, endonuclease, ERCM2, Excision repair cross-complementing rodent repair deficiency,complementation group 5, UVDR, XPG, XPGC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ercc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA excision repair protein (rad2)
- catalytic domain
- DNA secondary structure binding
- Xeroderma pigmentosum G I-region
- enzyme binding
- XPG I-region
- enzyme
- XPG N-terminal domain
- protein binding
- Helix-hairpin-helix class 2 (Pol1 family) motifs
- enzyme activator activity
- endonuclease
- H3TH_StructSpec-5'-nucleases
- binding protein
- damaged DNA binding
- single-stranded DNA binding
- double-stranded DNA binding
- protein homodimerization
- Xeroderma pigmentosum G N-region
Pathways
Biological processes and signaling networks where the Ercc5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- xeroderma pigmentosum
- cerebrooculofacioskeletal syndrome 3
- ovarian cancer
- xeroderma pigmentosum complementation group G
- developmental delay
- Cockayne syndrome
- xeroderma pigmentosum group G/Cockayne syndrome
- metastasis
- liver cancer
role in cell
- apoptosis
- expression in
- survival
- abnormal morphology
- binding in
- nucleotide excision repair in
- damage in
- reverse transcription in
- senescence
- reverse transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ercc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair, AP site formation
- negative regulation of apoptotic process
- transcription-coupled nucleotide-excision repair
- double-strand break repair via homologous recombination
- nucleotide-excision repair
- response to UV-C
- response to UV
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleotide-excision repair complex
- macromolecular complex
- DNA replication factor A complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- metal ion binding
- endonuclease activity
- bubble DNA binding
- double-stranded DNA binding
- enzyme activator activity
- endodeoxyribonuclease activity
- damaged DNA binding
- RNA polymerase II core binding
- single-stranded DNA binding