Gpn1 Gene Summary [Mouse]
Predicted to enable GTPase activity. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Is expressed in embryo; sublingual gland primordium; and submandibular gland primordium. Orthologous to human GPN1 (GPN-loop GTPase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpn1 |
| Official Name | GPN-loop GTPase 1 [Source:MGI Symbol;Acc:MGI:1921504] |
| Ensembl ID | ENSMUSG00000064037 |
| Bio databases IDs | |
| Aliases | GPN-loop GTPase 1 |
| Synonyms | 2410004J02Rik, AI449615, ATPBD1A, GPN-loop GTPase 1, LOC683898, MBDIN, NTPBP, RPAP4, XAB1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding domain
- transcription regulator
- protein binding
- acidic domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- Conserved hypothetical ATP binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- metabolic syndrome X
- COVID-19
- periodontitis
- oral cancer
role in cell
- cell death
- alternative splicing in
- accumulation in
- nuclear import in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpn1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATPase activity
- protein binding
- GTPase activity