Coro2a Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Located in brush border. Is expressed in several structures, including hemolymphoid system; nervous system; nose; submandibular gland primordium; and testis. Orthologous to human CORO2A (coronin 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coro2a |
| Official Name | coronin, actin binding protein 2A [Source:MGI Symbol;Acc:MGI:1345966] |
| Ensembl ID | ENSMUSG00000028337 |
| Bio databases IDs | |
| Aliases | coronin, actin binding protein 2A |
| Synonyms | 9030208C03RIK, CLIPINB, COR4, coronin 2A, coronin, actin binding protein 2A, IR10, WDR2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Coro2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Type of WD40 repeat
- WD40 repeats
- actin binding
- WD domain, G-beta repeat
- WD40
- protein binding
- Domain of unknown function (DUF1899)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- dementia
- preeclampsia
- pervasive developmental disorder
- uveal melanoma
- ocular melanoma
role in cell
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Coro2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- transcriptional repressor complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding