Coro1c Gene Summary [Mouse]
Enables small GTPase binding activity. Involved in several processes, including activation of GTPase activity; regulation of fibroblast migration; and regulation of ruffle assembly. Acts upstream of or within corpus callosum development and ventricular system development. Located in cytoskeleton. Part of flotillin complex. Is expressed in several structures, including brain; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Coro1c |
| Official Name | coronin, actin binding protein 1C [Source:MGI Symbol;Acc:MGI:1345964] |
| Ensembl ID | ENSMUSG00000004530 |
| Bio databases IDs | |
| Aliases | coronin, actin binding protein 1C |
| Synonyms | COR1C, coronin 1C, coronin, actin binding protein 1C, CRN2, HCRNN4, RGD1564490 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Coro1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- actin filament binding
- Type of WD40 repeat
- WD40 repeats
- enzyme binding
- WD domain, G-beta repeat
- WD40
- protein binding
- Domain of unknown function (DUF1899)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric cancer
- thrombocytosis
- Marfan syndrome
- coronary artery disease
- endometrial cancer
- infection by Influenza A virus subtype H1N1
role in cell
- apoptosis
- expression in
- proliferation
- invasion by
- migration
- phagocytosis by
- organization
- tubulation
- sprouting by
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- soluble fraction
- endoplasmic reticulum fraction
- mitochondrial fraction
- detergent resistant lipid raft fraction
- cytoskeleton
- cilia
- perinuclear region
- cortical rim
- actin cytoskeleton
- Plasma Membrane
- vesicles
- cell-cell contacts
- plasma membrane projections
- lateral plasma membrane
- endosomal membrane
- cell membrane leading edge
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Coro1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- signal transduction
- positive regulation of lamellipodium morphogenesis
- negative regulation of substrate adhesion-dependent cell spreading
- regulation of substrate adhesion-dependent cell spreading
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- actin filament organization
- regulation of ruffle assembly
- corpus callosum development
- ventricular system development
- establishment of protein localization
- negative regulation of focal adhesion assembly
- regulation of focal adhesion assembly
- neural crest cell migration
- regulation of protein phosphorylation
- negative regulation of protein phosphorylation
- phagocytosis
- endosomal transport
- negative regulation of epithelial cell migration
- regulation of epithelial cell migration
- regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- synapse
- focal adhesion
- sarcolemma
- cell cortex
- actin cytoskeleton
- vesicle
- ruffle membrane
- endosome membrane
- sarcomere
- lamellipodium
- flotillin complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- small GTPase binding