Aqp7 Gene Summary [Mouse]
Predicted to enable glycerol channel activity; urea channel activity; and water channel activity. Acts upstream of or within glycerol transmembrane transport and renal water absorption. Located in plasma membrane. Colocalizes with lipid droplet. Is expressed in early conceptus; genitourinary system; inner ear; and liver. Orthologous to several human genes including AQP7 (aquaporin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aqp7 |
| Official Name | aquaporin 7 [Source:MGI Symbol;Acc:MGI:1314647] |
| Ensembl ID | ENSMUSG00000028427 |
| Bio databases IDs | |
| Aliases | aquaporin 7 |
| Synonyms | AQP7L, AQPap, aquaporin 7, Aquaporin-7 like, GLYCQTL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aqp7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIP
- glycerol channel
- urea transporter
- protein binding
- water channel
- transporter
- urea channel
Pathways
Biological processes and signaling networks where the Aqp7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- obesity
- insulin resistance
- albuminuria
- hypoglycemia
- organismal death
- body mass index quantitative trait locus 17
- liver cancer
- epithelial cancer
role in cell
- function
- expression in
- proliferation
- apoptosis
- growth
- cell viability
- adhesion
- size
- mass
- permeabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- Cytoplasm
- cellular membrane
- Nucleus
- intercellular junctions
- lipid droplets
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aqp7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- water transport
- glycerol transport
- urea transmembrane transport
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytoplasmic vesicle membrane
- cell-cell junction
- cytoplasm
- cell cortex
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- glycerol channel activity
- water channel activity
- urea transmembrane transporter activity