Shroom3 Gene Summary [Mouse]
Enables actin binding activity. Acts upstream of or within several processes, including columnar/cuboidal epithelial cell development; neural tube closure; and regulation of cell shape. Located in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Is expressed in several structures, including central nervous system; gut; heart; paraxial mesenchyme; and sensory organ. Orthologous to human SHROOM3 (shroom family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shroom3 |
| Official Name | shroom family member 3 [Source:MGI Symbol;Acc:MGI:1351655] |
| Ensembl ID | ENSMUSG00000029381 |
| Bio databases IDs | |
| Aliases | shroom family member 3 |
| Synonyms | APXL3, D5Ertd287e, LOC100507233, MSTP013, RGD1310470, SHRM, Shrm3, ShrmL, shroom family member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shroom3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- actin binding
- canonical PDZ domain
- Apx/Shroom domain ASD2
- PDZ domain
- cpPDZ_Deg_HtrA-like
- Apx/Shroom domain ASD1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- coronary artery disease
- epithelial cancer
- eosinophilic esophagitis
- albuminuria
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- prostatic carcinoma
- prostate cancer
- cleft lip
role in cell
- organization
- aggregation
- localization
- co-localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- apical compartment
- intercellular junctions
- apical membrane
- actin stress fibers
- anchoring junction
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shroom3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cellular pigment accumulation
- cell morphogenesis
- apical protein localization
- actin filament organization
- pattern specification process
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoskeleton
- apical junction complex
- apical plasma membrane
- cortical actin cytoskeleton
- microtubule
Molecular Function
What the gene product does at the molecular level
- actin filament binding