Odc1 Gene Summary [Mouse]
Enables ornithine decarboxylase activity and protein homodimerization activity. Involved in putrescine biosynthetic process from arginine, via ornithine and regulation of protein catabolic process. Acts upstream of or within kidney development and positive regulation of cell population proliferation. Located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Used to study atrichia with papular lesions. Orthologous to human ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Odc1 |
| Official Name | ornithine decarboxylase, structural 1 [Source:MGI Symbol;Acc:MGI:97402] |
| Ensembl ID | ENSMUSG00000011179 |
| Bio databases IDs | |
| Aliases | ornithine decarboxylase, structural 1 |
| Synonyms | BABS, NEDBA, NEDBIA, ODC, ORNITHINE DECARBOXYLASE, ornithine decarboxylase 1, ornithine decarboxylase, structural 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Odc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes
- Pyridoxal-dependent decarboxylase, C-terminal sheet domain
- Pyridoxal-dependent decarboxylase, pyridoxal binding domain
- protein homodimerization
- ornithine decarboxylase
- diaminopimelate decarboxylase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Odc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- prostate cancer
- hyperplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- tumorigenesis
- recurrent rectal cancer
- adenoma formation
- epithelial neoplasia
role in cell
- expression in
- proliferation
- apoptosis
- activation
- differentiation
- morphology
- survival
- cell death
- growth
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Odc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- kidney development
- positive regulation of cell proliferation
- regulation of protein catabolic process
- polyamine metabolic process
- putrescine biosynthetic process from ornithine
- response to virus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- ornithine decarboxylase activity