Stoml2 Gene Summary [Mouse]
Predicted to enable GTPase binding activity; T cell receptor binding activity; and cardiolipin binding activity. Involved in several processes, including positive regulation of interleukin-2 production; proton motive force-driven mitochondrial ATP synthesis; and stress-induced mitochondrial fusion. Located in mitochondrion and plasma membrane. Orthologous to human STOML2 (stomatin like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stoml2 |
| Official Name | stomatin (Epb7.2)-like 2 [Source:MGI Symbol;Acc:MGI:1913842] |
| Ensembl ID | ENSMUSG00000028455 |
| Bio databases IDs | |
| Aliases | stomatin (Epb7.2)-like 2 |
| Synonyms | 0610038F01Rik, HSPC108, MSLP2, SLP-2, Stmatin-like 2, stomatin (Epb7.2)-like 2, stomatin like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stoml2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal region of band_7
- phospholipid binding
- SPFH_like
- binding protein
- prohibitin homologues
- enzyme binding
- T-cell receptor binding
- protein binding
- SPFH domain / Band 7 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- organismal death
- laryngeal carcinoma
- laryngeal cancer
- esophagus intraepithelial neoplasia
- colorectal cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
role in cell
- apoptosis
- expression in
- cellular infiltration by
- proliferation
- activation in
- phosphorylation in
- activation
- adhesion
- growth
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cytoskeleton
- cell surface
- cellular membrane
- actin cytoskeleton
- Nucleus
- endosomes
- vesicles
- Mitochondria
- immunological synapses
- mitochondrial intermembrane space
- mitochondrial inner membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stoml2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial protein processing
- lipid localization
- protein oligomerization
- T cell receptor signaling pathway
- CD4-positive, alpha-beta T cell activation
- mitochondrial ATP synthesis coupled proton transport
- mitochondrion organization
- positive regulation of interleukin-2 production
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrion
- membrane raft
- actin cytoskeleton
- plasma membrane
- mitochondrial inner membrane
- immunological synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase binding
- T cell receptor binding