Hint2 Gene Summary [Mouse]
Predicted to enable adenosine 5'-monophosphoramidase activity. Acts upstream of or within lipid catabolic process and negative regulation of peptidyl-lysine acetylation. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including brown fat; liver; lung; metanephros; and spleen. Orthologous to human HINT2 (histidine triad nucleotide binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Hint2 |
| Official Name | histidine triad nucleotide binding protein 2 [Source:MGI Symbol;Acc:MGI:1916167] |
| Ensembl ID | ENSMUSG00000028470 |
| Bio databases IDs | |
| Aliases | histidine triad nucleotide binding protein 2 |
| Synonyms | 1190005L05RIK, HINT-3, histidine triad nucleotide binding protein 2, HIT-17, HIT-17kDa |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hint2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- linear amide carbon-nitrogen bond hydrolase
- enzyme
- protein binding
- Scavenger mRNA decapping enzyme C-term binding
- HIT_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- macrovesicular hepatic steatosis
- hyperalbuminemia
role in cell
- production in
- function
- signaling in
- depolarization in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hint2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of peptidyl-lysine acetylation
- lipid catabolic process
- apoptotic process
- steroid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein binding
- adenosine 5'-monophosphoramidase activity
- hydrolase activity