Slc6a9 Gene Summary [Mouse]
Enables glycine:sodium symporter activity. Involved in several processes, including glycine import across plasma membrane; positive regulation of biosynthetic process; and regulation of glycinergic synaptic transmission. Acts upstream of or within glycine secretion, neurotransmission. Located in plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and liver and biliary system. Used to study glycine encephalopathy. Orthologous to human SLC6A9 (solute carrier family 6 member 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc6a9 |
| Official Name | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 [Source:MGI Symbol;Acc:MGI:95760] |
| Ensembl ID | ENSMUSG00000028542 |
| Bio databases IDs | |
| Aliases | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 |
| Synonyms | GCENSG, GLYT, GLYT-1, GLYT-1b, solute carrier family 6 member 9, solute carrier family 6 (neurotransmitter transporter, glycine), member 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc6a9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycine:sodium symporter
- glycine transporter
- Sodium:neurotransmitter symporter family
- protein binding
- Solute carrier families 5 and 6-like; solute binding domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- glycine encephalopathy with normal serum glycine
- alcoholism
- pervasive developmental disorder
- bacterial meningitis
- dyspnea
- suicide attempt
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- attention deficit hyperactivity disorder
regulates
- glycine
- neurotransmitter
- heme
- ethanol
- GLYR
- SLC6A9
- NMDA receptor
role in cell
- volume
- bortezomib sensitivity
- action potential
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- cellular membrane
- endosomes
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- synapse
- dense-core vesicles
- secretory granules
- dendrites
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc6a9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurotransmitter transport
- synaptic transmission, glycinergic
- glycine transport
- positive regulation of hemoglobin biosynthetic process
- regulation of synaptic transmission, glycinergic
- sodium ion transmembrane transport
- positive regulation of heme biosynthetic process
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- postsynaptic density
- lateral plasma membrane
- plasma membrane
- basal plasma membrane
- endosome
- postsynaptic membrane
- membrane
- synaptic vesicle membrane
- dense core granule
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- glycine:sodium symporter activity
- glycine transmembrane transporter activity