Ift74 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within several processes, including keratinocyte development; negative regulation of keratinocyte proliferation; and non-motile cilium assembly. Located in centrosome; cilium; and nucleus. Part of intraciliary transport particle B. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Used to study visceral heterotaxy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22; Joubert syndrome; and spermatogenic failure 58. Orthologous to human IFT74 (intraflagellar transport 74). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ift74 |
| Official Name | intraflagellar transport 74 [Source:MGI Symbol;Acc:MGI:1914944] |
| Ensembl ID | ENSMUSG00000028576 |
| Bio databases IDs | |
| Aliases | intraflagellar transport 74 |
| Synonyms | 1700029H06Rik, b2b796Clo, BBS22, CCDC2, CMG-1, intraflagellar transport 74, JBTS40, SPGF58 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ift74 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- helix-rich Mycoplasma protein
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Joubert syndrome type 40
- Bardet-Biedl syndrome type 22
- hereditary disorder
- spermatogenic failure 58
- congenital heart disease
- Jeune syndrome
regulates
- DNA promoter
- DNA endogenous promoter
- CCND2
- RNA polymerase II
role in cell
- cell death
- proliferation
- development
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- ciliary tip
- cilia
- Nucleus
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ift74 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of keratinocyte proliferation
- heart development
- Notch signaling pathway
- keratinocyte proliferation
- cilium morphogenesis
- intraflagellar transport involved in cilium morphogenesis
- positive regulation of cell adhesion mediated by integrin
- positive regulation of transcription from RNA polymerase II promoter
- intraflagellar anterograde transport
- determination of left/right symmetry
- keratinocyte development
Cellular Component
Where in the cell the gene product is active
- nucleus
- motile cilium
- centrosome
- acrosomal vesicle
- cilium
- intraflagellar transport particle B
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-tubulin binding
- chromatin binding