Kcnq4 Gene Summary [Mouse]
Enables voltage-gated potassium channel activity. Acts upstream of or within inner ear morphogenesis; potassium ion transport; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in several structures, including gonad; hemolymphoid system gland; inner ear; retina; and vestibulo-cochlear ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 2A and sensorineural hearing loss. Orthologous to human KCNQ4 (potassium voltage-gated channel subfamily Q member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnq4 |
| Official Name | potassium voltage-gated channel, subfamily Q, member 4 [Source:MGI Symbol;Acc:MGI:1926803] |
| Ensembl ID | ENSMUSG00000028631 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, subfamily Q, member 4 |
| Synonyms | DFNA2, DFNA2A, KV7.4, potassium voltage-gated channel subfamily Q member 4, potassium voltage-gated channel, subfamily Q, member 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnq4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- KCNQ voltage-gated potassium channel
- voltage-gated potassium channel
- Ion transport protein
- protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cutaneous melanoma
- hepatocellular carcinoma
- rectum cancer
- breast cancer
- autosomal dominant deafness
- hereditary disorder
- autosomal dominant nonsyndromic deafness type 2A
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- expression in
- apoptosis
- proliferation
- differentiation
- formation in
- formation
- migration
- invasion by
- multinucleation in
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- nerve ending
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnq4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- sensory perception of sound
- potassium ion transmembrane transport
- inner ear morphogenesis
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- voltage-gated potassium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- potassium channel activity