Rragc Gene Summary [Mouse]
Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein localization to lysosome. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Orthologous to human RRAGC (Ras related GTP binding C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rragc |
| Official Name | Ras-related GTP binding C [Source:MGI Symbol;Acc:MGI:1858751] |
| Ensembl ID | ENSMUSG00000028646 |
| Bio databases IDs | |
| Aliases | Ras-related GTP binding C |
| Synonyms | GTR2, LNGODS, LNGOS, RAGC, Ras-related GTP binding C, Rragc predicted, TIB929, YGR163W |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rragc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Gtr1/RagA G protein conserved region
- protein binding activity, bridging
- GTPase
- enzyme binding
- coiled-coil domain
- leucine zipper domain
- enzyme
- protein binding
- nucleotide-binding domain
- GTP binding
- GDP binding
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- follicular B-cell or T-cell lymphoma
- non-Hodgkin disease
- Long-Olsen-Distelmaier syndrome
role in cell
- phosphorylation in
- binding in
- activation in
- differentiation
- response by
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- lysosome
- cytosol
- lysosome membrane
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rragc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- small GTPase mediated signal transduction
- transcription, DNA-dependent
- cellular response to amino acid starvation
- protein localization
- response to amino acid stimulus
- cellular response to starvation
- cellular response to amino acid stimulus
- cellular response to nutrient levels
- negative regulation of autophagy
- apoptotic process
- protein localization in membrane
- regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- lysosomal membrane
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- magnesium ion binding
- protein binding
- protein heterodimerization activity
- protein anchor
- GTPase binding
- GTPase activity
- GDP binding
- binding, bridging