Zfyve26 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein kinase binding activity. Acts upstream of or within lysosome organization. Predicted to be located in early endosome; late endosome; and lysosome. Predicted to be active in centrosome and midbody. Is expressed in central nervous system; retina inner nuclear layer; and retina outer nuclear layer. Used to study hereditary spastic paraplegia 15. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfyve26 |
| Official Name | zinc finger, FYVE domain containing 26 [Source:MGI Symbol;Acc:MGI:1924767] |
| Ensembl ID | ENSMUSG00000066440 |
| Bio databases IDs | |
| Aliases | zinc finger, FYVE domain containing 26 |
| Synonyms | 4930465A13, 9330197E15RIK, A630028O16Rik, FYVE-CENT, Gm893, KIAA0321, mKIAA0321, SPG15, zinc finger, FYVE domain containing 26, zinc finger FYVE-type containing 26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfyve26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- protein kinase binding
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PHD finger superfamily
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spastic paraplegia
- spastic paraplegia type 15
- luminal A breast carcinoma
- luminal A breast cancer
- astrocytosis
- hereditary spastic paraplegia
- hereditary disorder
- gait disturbance
- kyphosis
- prostate cancer
role in cell
- abnormal morphology
- quantity
- degeneration
- cytokinesis in
- cytokinesis
- outgrowth
- organization
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- lysosome
- centriole
- midbody
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfyve26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- cytokinesis after mitosis
- regulation of cytokinesis
- double-strand break repair via homologous recombination
Cellular Component
Where in the cell the gene product is active
- centrosome
- early endosome
- late endosome
- midbody
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- metal ion binding
- phosphatidylinositol-3-phosphate binding